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915 In P 1B-2 transporters, a bidentate Asp completes a distorted tetrahedral complex in the E1 state, except for the Pb II enzyme, which excludes one the O ligands of Asp replacing it with its stereochemically active lone pair (Figure 54, bottom )
Vitamin B12 deficiency occurs when the body lacks enough of the vitamin to produce adequate red blood cells, leading to symptoms such as fatigue, weakness, and neurological issues
