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To validate the functional importance of the secondary IGF1-binding site, we introduced Y487A and R488A mutations into IGF1R, and tested their effects on IGF1R activation
H.StormM.CarringtonC.CassoD.GilroyK.PladsonL.et al
Signal Transduct Target Ther 2:17023
117 Additionally, considered as a key antioxidative enzyme, NNT is critical for inducing macrophage inflammatory responses 118 and preventing ROS-induced cytotoxicity in T cells exposed to asbestos that can cause a reduction in antitumor immunity
