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Description
[1] Most cases are initially observed as an endocrine disorder in children that occurs equally in males and females, although males are often diagnosed more frequently

The maternal adaptive immune system raises a response against antigens on fetal red blood cells and produces anti-fetal IgG Abs with the ability to cross the placenta via FcRn-mediated transport

That difference becomes more noticeable with larger quantities

Identification of critical IgG binding epitopes on the neonatal Fc receptor
