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FDA asked Medline Industries to respond to its warning letter within 15 business days and noted that since the December 2025 inspection, the agency has updated its Quality System (QS) regulation to the Quality Management System Regulation (QMSR) to harmonize with international regulatory standards

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Effects of copper deficiency on cardiovascular disease Not only does an excess of copper lead to cardiovascular disease, but copper deficiency may also result in alterations to cardiac morphology, swelling of the mitochondria, and fragmentation and enlargement of myocytes (93)