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The crossover study of an oral methionine load by Bellamy et al (1998) also supports the view that elevated homocysteine levels may promote vascular disease by impairing flow-mediated endothelium dependent vasodilation

Journal of Physiology 498, 1997

Systemic Detoxification: Uses powerful antioxidants to neutralize free radicals and reduce systemic inflammation, which is often the precursor to chronic illness

Third, this was a single-center study with a relatively small sample size, thus, requiring validation through larger-scale multicenter studies in the future
