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Impaired renal uric acid elimination is the abnormality that causes hyperuricemia in the majority of gout patients, but it is not the sole or dominant cause of hyperuricemia in all cases of gout

In addition, metabolites associated with amino acid metabolism and redox balance, such as lysine, arginine, and spermine, display multiple interactions with other metabolic nodes

In a follow-up study, Jones et al

[17] A graphical version is shown below for quick reference
