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Halder and Bridgeman-Shah
10.1016/j.molonc.2016.06.002 Mol
[1] The cyclic disulfide structure is thought to contribute to conformational rigidity and resistance to peptide degradation in biological environments. Pharmacokinetic studies in murine plasma indicated a plasma half-life of approximately 4 minutes under in vitro conditions, reflecting rapid enzymatic metabolism of the peptide backbone
Additionally, curcumin exhibited the potential to augment the apoptotic impact of ABT-737 in breast cancer cells by suppressing Mcl-1
