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LL-37 is already overexpressed in your plaques and helps activate the dendritic cells that drive the disease (Lande et al., Nature, 2007)
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Moreover, Lonicera japonica flower extracts (Ruan et al., 2019) and Salvia miltiorrhiza extracts (Yang et al., 2019) ameliorated AP progression by suppressing the ROS-NLRP3 inflammasome axis and reducing the expression of IL-1 and IL-18
Insmed has initiated a Phase II clinical study of brensocatib for chronic rhinosinusitis with nasal polyps (CRSsNP) (NCT06013241) ( Cystic fibrosis presents another opportunity
