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These include KD-induced alterations of the endocrine system, gut microbiome, epigenetic mechanisms, and expression of phosphoglycerate dehydrogenase (PHGDH), the first and rate-limiting enzyme of the de novo serine biosynthesis pathway
Driven by the Fenton reaction, ferroptosis results in lipid peroxidation through elevated intracellular iron levels and excessive production of reactive oxygen species (ROS)
To avoid potential metabolic incorporation of NAM probes through alternative catabolic pathways, an E
