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Riboflavin deficiency may be associated with an increased risk of anemia during pregnancy, and RCTs conducted in pregnant populations have demonstrated that the inclusion of riboflavin with other micronutrient supplements (namely iron and folic acid) leads to greater improvements in hematological parameters, such as hemoglobin concentration, RBC count, and anemia prevalence (reviewed in 62)

Depletion of P21 is often accompanied by the blocking of the Nrf2 pathway, while CGA can promote the activation of Nrf2/HO-1 pathway by reversing the downregulation of P21 , thus making it serve a continuous anti-oxidant role in oxidative stress (20)