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The researchers discovered that glutamine metabolism is impaired in the obese state, leading to increased chromatin O-GlcNAcylation and activation of genes in proinflammatory pathways

The default independent filtering function was replaced with independent hypotheses weighing from the IHW package ( v1.22.0 ) to increase statistical power by adjusting p values based on the mean expression level of each gene which was followed with multiple testing correction using the BenjaminiHochberg adjustment [35]