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Since this 2012 publication, there has been very little new research into this question

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Problems with B12 deficiency A lack of B12 in your body affects several nervous system and red blood cell functions, which can lead to things like: Anemia: causes fewer red blood cells to move from your bone marrow Birth problems: increases risk of pregnancy loss and neural tube defects Osteoporosis: leads to poor bone health and fracture risk Macular degeneration: progression of age-related macular degeneration Memory loss: the onset of early-stage dementia is greater The advantages of B12 injections The decision to get a B12 shot instead of a supplement depends on factors such as your level of vitamin deficiency, the presence of symptoms, and how your need changes over time

Vitamin B12 deficiency becomes increasingly more common as we age affecting up to 20% of adults over 60