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In fact, melatonin ameliorated the antioxidant defenses of the animals by improving the Nrf2 and BNDF expression

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Reactive astrogliosis is an evolutionarily conserved, graded, context-specific and multistage defensive response of astrocytes to neuropathology governed by complex molecular programs that translate into biochemical, morphological, metabolic and physiological features of astroglia, leading to an upregulation or loss of homeostatic cascades, or to the gain of new protective or regenerative functions 9,118