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Other studies have found that oral administration of KO significantly promoted wound healing of colonic anastomosis after colectomy in rats under the influence of inflammatory cell infiltration, fibroblast activity, angiogenesis, and collagen deposition (129)

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The therapeutic activation of this pathway with compounds such as dimethyl fumarate, tert-butylhydroquinone and sulforaphane can inhibit ferroptosis by upregulating the expression of downstream antioxidant genes (57)

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doi: 10.1371/journal.pone.0202458 103 ChitimusDMPopescuMRVoiculescuSEPanaitescuAMPavelBZagreanLet al

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