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Note: Control group (Glu: n = 9

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Necroptosis in cancer: Insight from epigenetic, post-transcriptional and post-translational modifications

[78] reported that fisetin can ameliorate type 2 diabetes-related vascular aging by targeting the PI3K/Akt/Bcl-2/Bcl-xl axis, promoting apoptosis of senescent endothelial cells, suppressing SASP factors, and enhancing the therapeutic efficacy of metformin, though direct dose equivalence and mechanistic comparisons were not established