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Growth Hormone and IGF Research 16(Suppl A):S55-S59. [doi.org]

BENEFITS OF METFORMIN Metformin has been prescribed off-label for PRESCRIPTIONS: Pre-diabetes Gestational Diabetes Polycystic Ovarian Syndrome (PCOS) Weight gain from anti-psychotic medications In addition, researchers are investigating the potential of metformin to: Lower the risk of cancer in persons with type 2 diabetes in PRESCRIPTIONS Lower risks for dementia and stroke Slow aging, prevent age-related disease, and increase lifespan 13% of Americans have diabetes 1 in 3 have pre-diabetes 1 in 3 have pre-diabetes HOW IS METFORMIN ADMINISTERED

The mRNA levels of CCL2 (C-C Motif Chemokine Ligand 2), CCL11 (C-C Motif Chemokine Ligand 11), CSF2 (Colony Stimulating Factor 2), CXCL10 (C-X-C Motif Chemokine Ligand 10), HGF (Hepatocyte Growth Factor), IL1RA (Interleukin 1 Receptor Antagonist), IL6 (Interleukin 6), IL10 (Interleukin 10), IL31 (Interleukin 31), LIF (LIF Interleukin 6 Family Cytokine), and NGF (Nerve Growth Factor) were quantified using specific primers in SYBR Green (Thermo Fisher) or TaqMan (Thermo Fisher) platforms following the manufacturers instructions