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For medical purposes, some doctors may recommend a weekly B12 shot for up to four weeks

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In this case, the neurotoxicity of cytosolic dopamine would prevent the benefits of lowering DOPAL levels [40]

The hypersecretion of cortisol (corticosterone in rodents) causes neuronal damage and structural disturbances in the hippocampus, resulting in depression symptoms ( Two third of depression patients are female, largely due to the frequent fluctuation of sex hormones in addition to environmental and genetic factors ( Stress is known to increase cortisol level and subsequently decrease the release of thyroid stimulating hormone (TSH) (37, 38)