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doi: 133

High-mobility group box 1 inhibitor Boxa alleviates neuroinflammation-induced retinal ganglion cell damage in traumatic optic neuropathy

While enzymes such as glutathione peroxidase 4 (GPx4) typically utilize cellular glutathione (GSH) stores to scavenge lipid hydroperoxides and prevent LPO-induced damage, erastin-mediated inhibition of cysteine uptake through the Xc- transporter compromises this defense strategy, leading to cell death

11 Chronic Obstructive Pulmonary Disease and Reactive Oxygen Species Lungs are particularly vulnerable to oxidative stress due to the high oxygen environment and exposure to environmental pathogens and oxidants