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It stimulates the synthesis of key ECM components, including collagen I and III, elastin, and various glycosaminoglycans (GAGs), by signaling through pathways such as the TGF-/SMAD cascade

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In fact the ADAGIO-study has given profound evidence for a disease-modifying effect of 1 mg/day rasagiline, while there was not such benefit at a 2 mg/day dosis (Table 4)