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Thus, GlnR*GS represents a transcriptional repressor complex that silences the genes involved in nitrogen assimilation

Mechanistically, total intracellular iron alone is not the whole storyhow a tumor uses iron (for DNA repair, energy metabolism, redox buffering, etc.) and the cells lineage-specific biology determine whether ferritin acts mainly as a protective iron reservoir or as a regulator of metabolism and redox state [3, 88]

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Also, the concept of multimodal therapy, which combines pharmacological treatments with physical therapy, psychological therapy, and interventional procedures, has become the cornerstone of modern pain management