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The decision, described by Katherine Hempstead, senior policy adviser at the Robert Wood Johnson Foundation, as the end of an era of being open to a broader conception of health within the Medicaid program, has sparked debate about the future of Medicaids role in addressing social needs and the balance between federal oversight and state flexibility

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The endo-lysosomal pathway is a major bottleneck limiting the clinical efficacy of therapeutic agents, as nanoparticles are often sequestered and degraded following endocytosis, reducing bioavailability ( in vitro , as evidenced by the dispersion of gene cargo around the nucleus and a transient peak in the colocalization coefficient followed by a decrease, indicating successful endosomal escape