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A significant increase in the intracellular Ca 2+ influx was observed in 3T1AM-exposed immortalized human CECs, suggesting that 3T1AM-type analogs should be used as the leading compounds in developing drugs that would directly activate TRPM8 and reduce desiccation of the anterior ocular surface epithelia [35]

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Lotus leaf extracts significantly inhibit the release of inflammatory cytokines IL-1, IL-6, TNF-, and IFN- and promote the release of anti-inflammatory IL-4 and IL-10 to alleviate chronic low-level inflammation accompanied by obesity