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If these develop, ultrasound evaluation is necessary

Cancer Research 80, (2020)

Contents Historical background Main function Additional functions Sites of the pentose phosphate pathway Oxidative phase of the pentose phosphate pathway Oxidation of glucose 6-phosphate to 6-phosphoglucono--lactone G6PD expression and immune function Catalytic mechanism of G6PD Regulation of G6PD Hydrolysis of 6-phosphoglucono--lactone to 6-phosphogluconate Oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate Catalytic mechanism of 6-phosphogluconate dehydrogenase Non-oxidative phase of the pentose phosphate pathway Isomerization of ribulose 5-phosphate to ribose 5-phosphate Catalytic mechanism of phosphopentose isomerase Epimerization of ribulose 5-phosphate to xylulose 5-phosphate Catalytic mechanism of phosphopentose epimerase Transketolase Catalytic mechanism of transketolase Transaldolase Catalytic mechanism of transaldolase Step 1: aldol cleavage and intermediate formation Step 2: aldol condensation and product release The cells need for NADPH, ribose 5-phosphate, and ATP When the need for NADPH is much greater than that for ribose 5-phosphate or ATP When the need for NADPH and ATP is much greater than that for ribose 5-phosphate When the need for ribose 5-phosphate is much greater than that for NADPH When the needs for ribose 5-phosphate and NADPH are balanced References Historical background The first evidence of the pentose phosphate pathway emerged in the 1930s through the work of Otto Warburg , who received the Nobel Prize in Physiology or Medicine in 1931 for his work on cellular metabolism and respiratory enzymes

Peptides are involved in nutrient metabolism, ensuring that the energy gleaned from food is used efficiently rather than stored as fat