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rAA is measured in one aliquot of a sample and total AA (that is, rAA and DHA) in a second aliquot of the same sample in which the DHA is reduced by incubation with tris(2-carboxyethyl) phosphine hydrochloride (TCEP, 0.5 mM) in the dark for 30 min at room temperature

In turn, in the VPA-induced rodent model of ASD, 4-week treatment with risperidone at both tested doses (1 and 3 mg/kg) increased Adar2 relative gene expression and decreased GluA2 Q:R ratio in the hippocampus and the PFC

141 Nanoresponsive nanobioconjugates release their cargo in response to some specific environmental factor, such as pH, redox potential, or enzyme activity, and have been shown to work well in hypoxic tumor microenvironments

Moreover, the upregulation of miR-150 expression in BV-2 cells demonstrated a significant inhibitory effect on neuroinflammation upon microglial activation by LPS