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With the ease of administration, it also possesses the same advantages as sublingual therapy for patients and has been shown to be a preferred treatment modality to the IM route ( Subcutaneous B12 Subcutaneous B12 is occasionally used, especially in patients with inborn errors of cobalamin metabolism, who need high pharmacological doses of B12 to maintain their B12-dependent metabolic pathways and related biochemistry within normal range

[1] [4] Mood changes including low mood, irritability, or anxiety can be associated with declining B12 levels, though these symptoms are non-specific and can have many causes

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