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Protein misfolding and failure of clearance systems, including the autophagy-lysosome and ubiquitin-proteasome pathways, further compromise the cellular environment and lead to toxic intracellular accumulations [31, 32]

Hope to weigh him soon

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So far only Ser375 phosphorylation has been shown to occur in vivo in intact mouse brain in an agonist-dependent manner (Grecksch et al., 2011)