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A significant concern is that supplements can alter drug metabolismeither reducing the effectiveness of cancer treatments or increasing their toxicity
Exposures to LPS, streptozotocin, and monocrotaline also resulted in downregulation of sEH, which reduces the conversion of epoxy-PUFAs to dihydroxy-PUFAs, preserving the anti-inflammatory properties of epoxy-PUFAs (Harris and Hammock, 2013)
On the other hand, In contrast to previously described iron inducers, FINO2 neither inhibits systemic XC -, nor directly targets the reductase GPX4 as erastin and RSL3 do, nor consumes the GPX4 protein as FIN56 does
Weifang 38 (05), 338341
