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XueYBarkerNHoonSHePThakurTAbdeenSRet alBortezomib stabilizes and activates p53 in proliferative compartments of both normal and tumor tissues in vivo
91 Therefore, clinical studies on conservative treatment are lacking, and, likewise, the natural course is largely unknown
Further investigation revealed that the IC50 concentration of CGA, through the depletion of free iron within hepatocytes, significantly reduced the expression of iron-sulfur cluster subunits in mitochondrial complexes I-III and disrupted the oxidative-reductive homeostasis of hepatocytes, ultimately leading to hepatotoxicity
