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glutathione polymer A Mechanism of driven redox-responsive reaction. B Cellular Glutathione-triggered biodegradable poly(disulfide)s: ring-opening copolymerization
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Excess ROS leads to increased mitochondrial membrane permeability, impaired mitochondrial redox status, respiratory chain damage, and potassium ion efflux, ultimately leading to an irreversible cascade amplification reaction (Marullo et al., 2013)

Figure 4 shows the main cellular sources of ROS

A study published in Diabetes Care found that pen injectors were significantly more accurate than insulin syringes at low doses, where small volume errors translate to large percentage differences in the actual amount delivered
