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Menzies, V

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Nitrofurantoin (NFT) demonstrated Nrf2 activation and glutathione synthesis stimulation comparable to the potent experimental Nrf2 activator diethyl maleate
Moreover, combining active targeting with stimuli-responsive release mechanisms such as pH or ROS-sensitive adapters can enable specific release of CeT in the acidic or oxidative environment of tumors, thereby optimizing efficacy and minimizing side effects (Fig 3)
