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The results showed that both polyphenols, at lower concentrations than 5-ASA, activated Nrf2, increased HO1 and glutamate cysteine ligase mRNA expression, enhanced the reduced-to-oxidized glutathione ratio, and inhibited reactive species production, with resveratrol and 5-ASA also increasing nuclear PPAR- levels

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Design, synthesis and pharmacological evaluation of 4-(3-chloro-4-(3-cyclopropylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxamide (WXFL-152): a novel triple angiokinase inhibitor for cancer therapy