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Incorporating site-specific or tissue-specific ligands into the liposome can provide it with active targeting capabilities

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The activation of clockophagy selectively degrades ARNTL through cargo receptor sequestosome 1 (SQSTM1), destabilizing HIF1A protein, and ultimately exacerbating lipid peroxidation and ferroptosis[71]

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Under normal physiological conditions, ROS participates in cellular signaling, regulating cell growth and maintaining homeostasis

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