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Description
In response, ROS/RNS can have harmful effects on cellular components, including mitochondria, which further promotes the generation of free radicals and increases intracellular oxidative stress

They consist of mitochondrial dysfunction affecting the cellular energy metabolism, calcium homeostasis in the heart affecting contractility of the myocardium, changes caused to the protein structure and function such as proteins in the extracellular matrix and contractile proteins, and post translational modifications that occur like O-GlcNAcylation and lysine - hydroxybutyrylation which are dysregulated in the diabetic heart (112)

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