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This finding not only supports the notion that phosphorylation events primarily occur in neurons within the cerebellum but also suggests a preference for subcellular enrichment in neuronal cell body, somatodendritic compartment and neuron projection cytoplasm, indicating that the cytoplasm is a key site for phosphorylation events where dimeric activated ATM can be found 40

Additionally, inhibition of PKCs with enzastaurin and of MAPK signaling with U0126 and GW5074 also abolished NET formation (Extended Data Fig

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