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It's important to note there are some folks who may be more at risk of a vitamin B12 deficiency than others, including those on plant-based diets, Kamitaki said

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Unlike fat-soluble vitamins (A, D, E, and K), which are stored in fat tissue for long periods, water-soluble vitamins are processed relatively quickly: your body takes what it needs, stores a small amount in the liver, and passes most of the rest in urine

Note that the AREDS2 formula contains 80mg, which is much higher than daily nutritional needs but has been proven effective and safe for those with intermediate to advanced macular degeneration