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Clinical insight: Patients who start anti-nausea meds in week 1 report 40% less severe nausea during peak weeks 6-8 compared to those who wait until symptoms are intolerable

Baltaci, D., Kutlucan, A., Turker, Y., Yilmaz, A., Karacam, S., & Deler, H

When it is overloaded, the effects can show up as fatigue, sluggish digestion, skin problems and that persistent feeling of being run down

GCL is subject to complex regulation: it is feedback-inhibited by GSH (non-allosteric competitive inhibition with respect to glutamate, K i 2 mM), transcriptionally upregulated by the Nrf2/ARE pathway in response to oxidative and electrophilic stress, and limited by cysteine availability the rate-limiting substrate in most cell types