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This enzyme converts oxidized glutathione into its reduced form

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Lack of suppression of circulating free fatty acids and hypercholesterolemia during weight loss on a high-fat, low-carbohydrate diet

Notably, the oncogenic drivers prevalent in PDAC, such as mutant KRAS and loss of TP53 or SMAD4, intricately modulate key ferroptotic pathways, including the System Xc/GSH/GPX4 axis, the FSP1-CoQH system, and lipid metabolism networks, thereby dictating cellular susceptibility to ferroptotic stress