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B: However, in the endothelial cells with high level of phosphor AKT, following the block of VEGF stimulation, the AKT pathway remains active inducing transcription of FGF, an angiogenic factor, which on one side promotes endothelium proliferation and on the other further phosphorylates AKT producing a positive loop

P301S, K257T), 0.5 g IN-NAP daily for ~5 months improved Morris water maze performance to that of controls, increased levels of soluble tau, and decreased neurotoxic hyperphosphorylated tau [106,107]

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