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Strategies for improving the safety and RNAi efficacy of noncovalent peptide/siRNA nanocomplexes

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Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to -amyloid clearance

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The FDA-approved CSF1R inhibitor PLX3397 (pexidartinib) has demonstrated clinical efficacy in reducing TAM-mediated immunosuppression, and early-phase trials have evaluated its combination with ICIs to further enhance immune responses (162)

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