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It can range from mild to disabling and may or may not be neurodegenerative

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LOX, secreted as a 50 kDa immature precursor, is cleaved extracellularly into a 32 kDa active mature lysyl oxidase enzyme and an 18 kDa lysyl oxidase propeptide (LOX-PP) by the bone morphogenetic protein 1 (BMP-1) 8,9,10,11