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Another limitation is that the allocation of patients to different treatment groups was not randomized

Curcumin (200 mg/kg) significantly ameliorated brain injury and neurological deficits in rats subjected to middle cerebral artery occlusion by upregulating autophagy-related proteins p-Akt and p-mTOR, while downregulating autophagy-associated proteins LC3-II/LC3-I and inflammation-related proteins IL-1, TLR4, p-38 and p-p38

Adems, los testimonios no cuentan con grupos de comparacin, no controlan el efecto placebo y rara vez documentan de manera objetiva los efectos adversos, manifiestan los expertos del CIMED-UCR