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First, overexpression of the alsin long isoform protects against motor neuron toxicity induced by expression of A4T, or mutant SOD1 G85R or SOD1 G93A (Kanekura et al., 2004)

Abstract Adler GK, et al

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

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