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AMPK is an energy-sensing kinase that responds to the rise in AMP:ATP and ADP:ATP ratios and DNA damage [28]
10.1016/j.envint.2011.04.005 143 LongM.KnudsenA.-K
Although O 2 itself is poorly reactive with most biological substrates in aqueous environments [89], it serves as a progenitor for a number of other, more microbicidal ROS and plays a critical role in mediating a wide range of cellular signaling processes
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