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326,327 In addition, short-term exposure to hypoxia leads to increased renal expression of antioxidants such as nuclear factor erythroid 2-related factor 2, hemeoxygenase 1, and metallothionein I that protect against fibrosis and inflammation induced by reactive oxygen species

This theoretical framework provides guidance for the development of new therapeutic strategies: targeting key nodes in the cycle regulation (such as Wnt pathway activators), intervening in the immunehair follicle interface (such as JAK inhibitors), and reconstructing redox balance

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This means that EpCAM-specific antibodies are conjugated with cytotoxic agents, such as doxorubicin, paclitaxel, calicheamicin, topoisomerase I inhibitors, alpha amanitin, and indolinobenzodiazepine pseudodimers (IGNs), to specifically kill the EpCAM+ tumor cells