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Adverse events included elevated heart rate (mean increase of 79 bpm), dry mouth, insomnia, and mild hypertension
It is noteworthy to state that NRF1 and NRF2 are thought to activate the gene expression of the mitochondrial respiratory chain downstream from the PGC-1/ERR axis [37, 38]

RNA drugs and RNA targets for small molecules: principles, progress, and challenges
