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NAD+ plays an important role in cellular energy production and mitochondrial function, while glutathione helps protect cells from oxidative stress and supports detoxification pathways
10.1016/j.taap.2015.09.026 167 WangJ.-M.LiZ.-F.YangW.-X.TanF.-Q

Deficient leptin cellular signaling plays a key role in brain ultrastructural remodeling in obesity and type 2 diabetes mellitus