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Interestingly, S586A displayed an over 2-fold improvement in activity compared with the WT enzyme (96.0 2.0 Umg 1 versus 43.1 1.0 Umg 1 ), representing the highest activity among all variants tested
To understand this we first need some background on peak bone density, how bone renovates and balances itself and how menstrual cycle hormones are related to bone balance
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