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Here, we hypothesize that GGCT, a potential endogenous source of cysteine other than xCT-mediated cystine uptake, may contribute to resistance to therapies involving xCT inhibition, such as erastin

Aside from generating both NADPH and ribose 5-phosphate, the PPP can operate four different modes where NADPH and/or ribose 5-phosphate is produced, depending on the cellular metabolic demands (Fig