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Importantly, the abnormal expression of calsequestrin-1 is linked to high levels of oxidative stress production and mitochondrial damage (Paolini et al., 2015)
Third, iron can have numerous effects beyond inducing ferroptosis, such that the accumulation of iron is not synonymous with ferroptosis

Contact Lens Anterior Eye 31:5764 Ghanbari H, Viatge H, Kidane AG, Burriesci G, Tavakoli M, Seifalian AM (2009) Polymeric heart valves: new materials, emerging hopes

Crucially, targeting ZIP4 in conjunction with radiotherapy may be an effective new therapy for treating NPC
