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Excess iron is known to replace zinc in the N-terminal DNA-binding 'zinc finger' of the estrogen receptor, resulting in increased ROS formation

Certain toxin-induced models of demyelination are initiated by the injection of toxic compounds such as lysophosphatidylcholine (LPC), lipopolysaccharide (LPS), or ethidium bromide into white matter areas to create a focal lesion at the injection site

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Even though most of these techniques are in experimental stages only and need to go under clinical trials and evaluation, among all these emerging technologies, nanotechnology-based nanomedicines are gaining popularity among researchers for the theragnostic purposes of PD (16)